Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Hey Gillian 👋
Your baby missed something important at birth. Here's how to help them catch up.
Babies born by C-section miss a critical bacterial handoff that happens in the birth canal — one that builds their immune system, digestion, and long-term health. The good news? Persephone was designed to give them exactly what they missed.
The science, simplified
Babies are born with a sterile gut. In the first moments of life, they're seeded with bacteria that become their microbiome — the ecosystem governing immunity, digestion, and development.
During a vaginal birth, beneficial bacteria like Lactobacillus and Bifidobacterium coat the baby as they pass through the birth canal and colonize the gut immediately.
In a C-section, that handoff doesn't happen. Instead, early bacterial exposure often comes from hospital surfaces — a very different starting point.
The microbiome gap is real and it starts at birth
Our My Baby Biome study (the largest of its kind in the US) revealed that 9 out of 10 babies are missing critical gut bacteria at birth.
74%
of a vaginally born baby's early gut bacteria comes directly from mom's microbiome. 1
1 in 3
US babies born by C-section, missing this bacterial transfer. 2
Day 5
C-section babies still show near-zero levels of important gut bacteria.3
9 in 10
US babies missing keystone Bifidobacterium strains. 4
4
Keystone Strains
of infant/toddler specific probiotics
HMO
prebiotic blend
to promote bacterial longevity in the gut
100%
daily recommended value of Vitamin D for infants
What Pediatricians Are Saying
I recommend infant-specific probiotics like Persephone’s synbiotic, which is designed to restore what nature intended every baby to have in those critical first months of life. 
Dr. Tanya Altman, MD
Built For Babies Like Yours
Replenishes the bacteria C-section babies miss
Supports immune system development.
Promotes healthy digestion
Designed for the critical first 1,000 days
Precision science designed to restore what nature intended
We've identified the exact keystone strains of Bifidobacterium — the same bacteria missing in C-section babies, and paired them with HMO prebiotics found in breast milk. Together, they work as a system to seed, feed, and sustain a healthy microbiome from day one.
Real people. Real science. Here for you.
If you're not satisfied within 90 days, we'll make it right. No complicated process. No runaround.
Every purchase is backed by our 90 day Peace of Mind Promise
This isn’t just my company, it’s my calling.
I'm Stephanie, a mom, scientist and founder. Have questions about our product or your babies microbiome? We've got you.
FAQs
Babies born by cesarean section, or C-section, typically have a different early exposure. Instead of vaginal microbes, they are more likely to encounter bacteria from the skin, the hospital environment, and the operating room.
Yes. Both Bloom and Thrive are designed specifically for infants and toddlers, third-party tested at Eurofins for heavy metals, allergens, and contaminants, and certified by the Clean Label Project's First 1,000 Days Promise.
Most probiotics use generic strains isolated decades ago that have no ability to consume breast milk sugars. Persephone uses four proprietary strains from today's healthiest babies, precision-paired with the HMOs they've evolved to eat. It's a different category of product — not a better version of the same thing.
Every baby is different. Some parents notice changes in digestion and comfort within the first few weeks. Immune and long-term benefits build over months of consistent use. That's why we offer a 90-day guarantee. Meaningful gut health takes time, and we want you to have the space to see it work.
Some babies do best starting slow. Half a packet for the first few days. Minor adjustments are normal as the gut adapts. Our Care Team (real scientists and doctors, not a call center) is available to support you through the process personally.
Citations
- Shao, Y. et al. Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth. Nature 574, 117–121 (2019). https://doi.org/10.1038/s41586-019-1560-1.
- Centers for Disease Control and Prevention, National Center for Health Statistics. Births and Natality. (2023). https://www.cdc.gov/nchs/fastats/delivery.htm.
- Hurkala, J. et al. Effect of a Short-Time Probiotic Supplementation on the Abundance of the Main Constituents of the Gut Microbiota of Term Newborns Delivered by Cesarean Section. Nutrients 12, 3128 (2020). https://doi.org/10.3390/nu12103128.
- Jarman, J.B. et al. Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis. Commun Biol 8, 867 (2025). https://doi.org/10.1038/s42003-025-08274-7.