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Toddler / 12-36 months
Toddler / 12-36 months
Toddler / 12-36 months
Toddler / 12-36 months
Toddler / 12-36 months
Toddler / 12-36 months
Toddler / 12-36 months
Toddler / 12-36 months
Toddler / 12-36 months
Toddler / 12-36 months
4.6
Rated 4.6 out of 5 stars
65 Reviews

Infant / 0-12 months

Bloom Formulation l 30 Day Supply

$74.95 $64.95 | 30 Day Supply

A first-of-its-kind powdered synergistic synbiotic (probiotics + precision-matched prebiotics) for infants 0-12 months, including 100% of the AAP's daily recommended Vitamin D.

  • Establishes beneficial bacterial populations
  • Promotes gut health
  • Aids healthy immune development
  • Supports brain development
Infant 0-12 mo. Toddlers 12-36 mo.

Select Your Cadence

Clinically Studied

Non-GMO

Pediatrician-Endorsed

Probiotic Blend Made in the USA

A synergistic synbiotic is a scientific term, not a marketing phrase. It refers to a probiotic and a prebiotic that are tailored to one another. Most probiotic and prebiotic blends do not meet this definition.

Simply put, the right bacteria with the wrong food doesn’t do anything for our gut. And to take it a step further, the best bacteria with the perfect food becomes more than the sum of its parts. That’s a synergistic synbiotic. It’s what we are. It’s what most are not.

Give one packet daily. For bottle-fed babies, mix into a single daily bottle of breastmilk or formula. For breastfed babies, mix the powder with a few drops of breastmilk to create a paste and apply to your nipple, finger, or pacifier—or mix with a teaspoon of breastmilk and give with a small syringe. It’s flavorless, gentle, and designed for daily use starting from birth.

NO peanuts, eggs, tree nuts, soy, fish, shellfish, or sesame.

Gluten-Free and Kosher

Every batch of our synbiotic is third-party tested for pathogens, heavy metals, allergens, and potency—using pharmaceutical-grade standards. Certified by the Clean Label Project’s First 1,000 Days™ program and backed by years of research, our formula is safe for infants and toddlers, and rigorously tested to give you peace of mind.

Proprietary Probiotic Blend - 1 Billion AFU

  • Bifidobacterium infantis PB-01
  • Bifidobacterium infantis PB-02
  • Bifidobacterium longum PB-03
  • Bifidobacterium breve PB-04

Proprietary Human Milk Oligosaccharide Blend - 1g

  • 2’-Fucosyllactose
  • Laco-N-tetraose
  • 6’-Sialyllactose
  • 3’-Sialyllactose

Vitamin D (as cholecalciferol) - 400 IU

May contain traces of milk (lactose)
4.6
Rated 4.6 out of 5 stars
65 Reviews

Toddler / 12-36 months

Thrive Formulation l 30 Day Supply

$74.95 $64.95 | 30 Day Supply

A first-of-its-kind powdered synergistic synbiotic (probiotics + precision-matched prebiotics) for toddlers 12-36 months, including 400 IU of Vitamin D.

  • Establishes beneficial bacterial populations
  • Promotes gut health
  • Aids healthy immune development
  • Supports brain development
Infant 0-12 mo. Toddlers 12-36 mo.

Select Your Cadence

Clinically Studied

Non-GMO

Pediatrician-Endorsed

Probiotic Blend Made in the USA

A synergistic synbiotic is a scientific term, not a marketing phrase. It refers to a probiotic and a prebiotic that are tailored to one another. Most probiotic and prebiotic blends do not meet this definition.

Simply put, the right bacteria with the wrong food doesn’t do anything for our gut. And to take it a step further, the best bacteria with the perfect food becomes more than the sum of its parts. That’s a synergistic synbiotic. It’s what we are. It’s what most are not.

Mix one packet daily into cold or room-temp foods like yogurt, applesauce, or smoothies—or into milk (better than water for feeding the good bacteria). It’s tasteless, dissolves completely, and fits easily into your toddler’s daily routine. Consistency is key to helping their gut bacteria thrive.

NO peanuts, eggs, tree nuts, soy, fish, shellfish, or sesame.

Gluten-Free and Kosher

Every batch of our synbiotic is third-party tested for pathogens, heavy metals, allergens, and potency—using pharmaceutical-grade standards. Certified by the Clean Label Project’s First 1,000 Days™ program and backed by years of research, our formula is safe for infants and toddlers, and rigorously tested to give you peace of mind.

Proprietary Probiotic Blend - 5 Billion AFU

  • Bifidobacterium infantis PB-01
  • Bifidobacterium infantis PB-02
  • Bifidobacterium longum PB-03
  • Bifidobacterium breve PB-04

Proprietary Human Milk Oligosaccharide Blend - 1g

  • 2’-Fucosyllactose
  • Laco-N-tetraose
  • 6’-Sialyllactose
  • 3’-Sialyllactose

Vitamin D (as cholecalciferol) - 400 IU

May contain traces of milk (lactose)
Probiotic Blend Made in the USA
•
Clinically-Studied
•
Clean Label Project Certified
•
Every Batch Third-Party Tested & Deep DNA Sequenced
•
No Artificial Additives
•
Probiotic Blend Made in the USA
•
Clinically-Studied
•
Clean Label Project Certified
•
Every Batch Third-Party Tested & Deep DNA Sequenced
•
No Artificial Additives
•
Probiotic Blend Made in the USA
•
Clinically-Studied
•
Clean Label Project Certified
•
Every Batch Third-Party Tested & Deep DNA Sequenced
•
No Artificial Additives
•
Probiotic Blend Made in the USA
•
Clinically-Studied
•
Clean Label Project Certified
•
Every Batch Third-Party Tested & Deep DNA Sequenced
•
No Artificial Additives
•

The Persephone
Difference

A synergistic synbiotic to give every child’s body what it needs to develop a robust immune system. For life.

Science-Backed

Clinically validated and developed by leading microbiome scientists and pediatricians (who are also parents).

Tailored for Babies

Probiotic strains isolated from our My Baby Biome study to support your child’s developing gut.

Clean and Safe

Every batch is third-party tested, free of artificial additives, and certified by the Clean Label Project’s First 1,000 Days Promise.

Effortless for Parents

Flavorless, single-serving powder mixes seamlessly into breast milk, formula, any liquid or food.

Your child’s
immune system
begins in the gut

For generations, For generations, babies were born with a resilient gut microbiome, rich in protective bacteria that support immunity, digestion, and development.

Our My Baby Biome study indicates that's no long the norm.**

Learn More

Today

9

out
of

10

U.S babies are born without the essential levels of the critical gut bacteria they need for a developing immune system.

Restoring what
Mother Nature intended

Backed by years of clinical research, our synbiotic carefully restores the keystone bacteria babies are meant to have. So they can thrive as nature intended.

4

Keystone
Probiotic
Strains

Precision-Matched

HMO

Prebiotic Blend

100%

DV of Vitamin D
for infants

Convenient

Single-Serve Packets

Meet the Persephone Care Team

Real people.
Real science.
Here for you.

Have a question about your product, your microbiome, or how it all fits together? We’ve got you.

The Persephone Care Team is your direct line to the people behind our science. It’s a collaboration between our in-house customer support specialists and the very scientists, doctors, and researchers who created the product in your hands.

Whether you’re:

  • Navigating your first product experience
  • Curious about how it fits into your health routine
  • Or just want science in plain English

We’re here. We believe support should feel personal—and smart.
Ask us anything
 This is science with a heart ❤︎

Follow us

@persephone.bio

Pro and Pre FAQ’s

One packet, every day. Consistency is what helps their gut bacteria thrive.

Pro Tip: Keep the box next to wherever your routine starts, bottles, snacks, or even the coffee pot, so it’s easy to remember every day.

Mix into cold or room-temp foods (like yogurt, applesauce, or smoothies) or drinks (milk is better than water due to the HMOs). It dissolves completely and has no taste.

Pro Tip: Add to their favorite foods, or include your toddler in the process.

Nothing! It’s completely flavorless and dissolves fully. Your child won’t even know it’s there.

Pro Tip: If you have a picky toddler, mix it into a food or drink they already love — it blends right in without changing taste or texture.

It's can be completely normal, it just means their gut is adjusting. Try starting “low and slow” with a pinch, then half a packet for a few days, then work up to a full packet. If discomfort continues for more than two weeks, pause and check in with your pediatrician.
Have further questions? View all FAQs

Customer Reviews