Healthcare Providers

Restoring Bifidobacterium for Early Immune Health

Pediatric inflammatory conditions are rising at an alarming rate. The early microbiome plays a key role in establishing a healthy immune system. Without key species, children are at increased risk of developing immune-related conditions.

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Diapers and the discovery

Persephone started with a simple question: What’s actually happening in the infant gut microbiome today?

The answer came from our My Baby Biome Study, a large, diverse U.S. cohort with microbiome profiling from 400+ infants.

We found a widespread deficit of early-life Bifidobacterium, a pattern that helps explain why so many families and clinicians are looking for real, science-grounded microbiome support.

See the peer-reviewed publication

400+ diapers revealed that

90%

of U.S. babies are missing 1 or more keystone strains of Bifidobacterium

From poop to product

Redesigning health from the very beginning.

We turned that discovery into a solution

Most probiotic products were not built from modern infant microbiome data. And many aren’t designed to help strains meaningfully establish in the early-life gut.

Persephone used our research platform to identify which missing microbes matter most in early life, then paired them with targeted nutrients to support real biological function

The result is a synbiotic designed for early life. It's grounded in microbiome measurement, built with rigorous strain selection, and manufactured with transparency standards clinicians can stand behind.

The breakthrough synbiotic

Insights Into Solutions

I recommend infant-specific probiotics like Persephone’s synbiotic, which is designed to restore what nature intended every baby to have in those critical first months of life.

Dr. Tanya Altmann, MD

Safety you can trust,
testing you can see

When clinicians recommend a microbiome product for infants and toddlers, quality and transparency aren’t “nice-to-haves,” they’re the standard. Persephone uses third-party testing and clear documentation so you can evaluate what you’re recommending with confidence.

What we test for: