Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Hey Gillian 👋
The Gas.
The Fussiness.
The Restless Nights. It Might All Start In Their Gut.
The Fussiness.
The Restless Nights. It Might All Start In Their Gut.
9 out of 10 babies are missing a key gut bacteria they're meant to have. Without it, the gut can't fully find its balance, and that's when discomfort keeps circling back.
Persephone was built for exactly this. The good bacteria your baby needs, precision-paired with the food it needs to thrive.
IYKYK
You've Done Everything Right
You switched to a gentle formula, tried the gas drops, bought the gripe water at 2am.
Here's what most parents never hear: it might not be about the symptom.
Gas, fussiness, restless sleep, and digestive discomfort often start in the gut.
Comfort starts in the gut. After 4 weeks of use,‡ parents reported:
Better Sleep & General Mood
Less Colic/Fussiness
Calmer Digestion
Increased Bowel Movements
Less Gas
Pediatrician Recommended
"I recommend infant-specific probiotics like Persephone's synbiotic, which is designed to restore what nature intended every baby to have in those critical first months of life."
— Dr. Tanya Altman, MD, Pediatrician and Best-Selling Author
72% of parents reported fewer digestive issues within 30 days*
Digestive comfort is often one of the first changes parents notice. *Based on 1-month parent survey data from verified Persephone customers.
63% experienced reduced colic symptoms*
Parents report a noticeable reduction in colic symptoms within the first 30 days — fewer crying episodes, less gas, and a calmer, more settled baby. *Post-purchase customer survey.
47% noticed improvements in sleep*
Gut health and sleep are connected — especially in early infancy. *Based on parent-reported outcomes, verified purchase survey
90% of parents said they'd recommend Persephone to another parent*
The best proof is what parents tell each other. *based on verified customer reviews
Gas drops?
Designed to break up bubbles, They treat the symptom in the moment, but are not designed to support the developing gut.
Gripe Water?
Widely used. But not backed by strong clinical evidence. Most formulas haven't been rigorously tested for the gut health they imply they support.
The real question
What if the gas, the colic, and the broken sleep aren't separate problems? What if they're all signals from a gut that isn't getting what it needs every day?
Most modern babies are missing gut microbes they were built to have.
For generations, babies were born with a resilient gut microbiome, rich in protective bacteria that support immunity, digestion, and development.
Our research shows that's no longer the norm and most are now missing the keystone bacteria they're built to have, no matter how they're born or fed.
Modern life has quietly reshaped the microbes babies start with.
Bifidobacterium colonization is critical in the first 1,000 days to help the immune system develop
Persephone's daily synbiotic carefully restores the keystone bacteria babies are meant to have. So they can thrive as nature intended.
The Research That Started It All
7 YEARS
Of infant microbiome research behind every formula decision
400+ Samples
Of infant stool analyzed from 48 states. The largest U.S. study of its kind
50+ YEARS
Since B. Infantis started disappearing from the infant gut biome
1,000 DAYS
The critical window to build lifelong gut health — starting at birth
We partner with Eurofins, a global leader in independent lab testing, to rigorously screen each batch of our probiotic. These tests are conducted at the same scientific standard used in pharmaceutical and clinical settings.
Every lot is tested for:
Pathogens
including Salmonella, E. coli, Listeria, and mold
Heavy metals
like lead, arsenic, mercury, and cadmium
Common allergens
including dairy, soy, gluten, nuts, and shellfish
Microbial purity & potency
to ensure the good bugs are thriving, and the bad ones are gone
4
Keystone Strains
proprietary infant specific probiotics
HMO
Prebiotic Blend
the exact fuel the probiotics need to do their job
90
Day Peace of Mind Promise
We stand behind our product If you’re not satisfied for any reason, just reach out and we’ll make it right.
FAQs
We stand behind our product with a90-day Peace of Mind Promise. If you’re not satisfied for any reason, just reach out to our Care Team.
Every baby is different. Some parents notice changes in digestion and comfort within the first few weeks. Immune and long-term benefits build over months of consistent use. That's why we offer a 90-day guarantee. Meaningful gut health takes time, and we want you to have the space to see it work.
Yes. Both Bloom and Thrive are designed specifically for infants and toddlers, third-party tested at Eurofins for heavy metals, allergens, and contaminants, and certified by the Clean Label Project's First 1,000 Days Promise.
Yes. Mix one packet into a single daily bottle of formula.
Pro Tip: Mix it into a smaller bottle or portion so you know your baby finishes the full serving.
Most likely, yes. B. infantis has been declining in the Western gut for over 50 years — a multigenerational shift that predates your own mother's birth. Even the most health-conscious pregnancy can't fully reverse a trend that has been building for generations. Our My Baby Biome study found 9 in 10 babies missing B. infantis regardless of feeding method or birth type.
Absolutely. 7+ years of research on this specific product plus many additional years on the microbiome. We also test every batch with a 3rd party.
Citations
- Jarman, J.B. et al. Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis. Commun Biol 8, 867 (2025). https://doi.org/10.1038/s42003-025-08274-7
- Hossain, M.F. et al. The gut-sleep axis in adults and infants. Open Life Sci (2023). https://doi.org/10.1515/biol-2022-0910
- Lauritzen, L. et al. Bifidobacterium and sleep in infants: a study of 162 infants. Prog Neurobiol (2021). https://doi.org/10.1016/j.pneurobio.2021.102208
- Hepsomali, P. & Groeger, J.A. Diet, gut microbiota, and sleep. Sleep Med Rev (2021). https://doi.org/10.1016/j.smrv.2020.101340
- Mu, S., et al. (2023). Bifidobacterium and infantile colic. Scientific Reports. https://doi.org/10.1038/s41598-023-36641-z
‡Based on a survey of parents whose infants used Persephone for at least one month. Individual results may vary.