Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Hey Gillian 👋
Doctor-Recommended Microbiome Support for Your Baby
The first 1,000 days are critical to establishing a healthy immune system. Without it, children are at increased risk of developing immune-related conditions.
I recommend infant-specific probiotics like Persephone’s synbiotic, which is designed to restore what nature intended every baby to have in those critical first months of life. 
Dr. Tanya Altmann, MD
Mom, Pediatrician, Best-Selling Author
Persephone wasn't built to compete with other probiotics — it was built because nothing like it existed.
Seven years of research. Four precision-matched strains + the prebiotics they need to colonize. The most rigorous safety testing in infant supplements. And families who are seeing the difference every day.
It is clear that the infant gut microbiome today in industrialized societies is different than in the past with loss of keystone, pioneer microbes. The good news is that this significant deficit is addressable. 
Richard Insel, M.D.,
Pediatrician and Research Professor
probiotic for today’s
babies
4
Keystone Strains
every baby needs to build a healthy foundation for life
HMO
prebiotic blend
to promote bacterial longevity in the gut
100%
daily recommended value of Vitamin D for infants
Safety First
What's In It Matters as Much as What Isn't.
Science-Backed
Developed by leading microbiome scientists and pediatricians (who are also parents).
Tailored for Babies
Uniquely built to replenish key beneficial microbes missing in nine out of ten babies today.**
Clean and Safe
3rd-party tested. Screened for heavy metal and major allergens. Clean Label Project Certified.
Clinically Validated
For safety and effectiveness in a randomized, double-blind placebo-controlled study*
72% of parents reported fewer digestive issues within 30 days*
Digestive comfort is often one of the first changes parents notice. *Based on 1-month parent survey data from verified Persephone customers.
47% noticed improvements in sleep*
Gut health and sleep are connected — especially in early infancy. *Based on parent-reported outcomes, verified purchase survey
90% of parents said they'd recommend Persephone to another parent*
The best proof is what parents tell each other. *Based on verified customer reviews
63% experienced reduced colic symptoms*
Parents report a noticeable reduction in colic symptoms within the first 30 days — fewer crying episodes, less gas, and a calmer, more settled baby. *Post-purchase customer survey.
I've recommended Persephone to all the babies I take care of! Finally, a synbiotic that I am confident will be beneficial regardless of feeding method. The addition of HMOs, Vitamin D and strains of beneficial bacteria known to be deficient in all babies make it truly unique. My families report it's well tolerated, supports immunity and improves eczema even after short term use. 
Dr. Tiffany Fischman
Sollis Health and Pacific Ocean Pediatrics
Stephanie Culler, PhD
CEO & Co-Founder, Microbiome Scientist & Mom
I had studied the microbiome for over a decade, but it wasn’t until I became a mom that I realized what was missing in our babies.
Conversations with the leading pediatric experts and the results of our My Baby Biome study revealed a shocking global trend: most babies lack the gut microbes they need for lifelong health.
I was shocked that no one had solved this problem.
So I am. This isn’t just my company, it’s my calling.
Why Parents Choose Persephone
Persephone supports early-life health from the inside out. Trusted by parents and doctors, many families report improvements in digestion, sleep, fussiness, and overall comfort.
If you’re here through a doctor referral, your exclusive discount will be applied automatically at checkout.