Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Hey Gillian 👋
Persephone wasn't built to compete with other probiotics — it was built because nothing like it existed.
Seven years of research. Four precision-matched strains + the prebiotics they need to colonize. The most rigorous safety testing in infant supplements. And families who are seeing the difference every day.
Safety First
What's In It Matters as Much as What Isn't.
Science-Backed
Developed by leading microbiome scientists and pediatricians (who are also parents).
Clean and Safe
3rd-party tested. Screened for heavy metal and major allergens. Clean Label Project Certified.
Clinically Validated
For safety and effectiveness in a randomized, double-blind placebo-controlled study*
Tailored for Babies
Uniquely built to replenish key beneficial microbes missing in nine out of ten babies today.**
Real Families. Real Results.
72% of parents reported fewer digestive issues within 30 days*
Digestive comfort is often one of the first changes parents notice. *Based on 1-month parent survey data from verified Persephone customers.
47% noticed improvements in sleep*
Gut health and sleep are connected — especially in early infancy. *Based on parent-reported outcomes, verified purchase survey
90% of parents said they'd recommend Persephone to another parent*
The best proof is what parents tell each other. *based on verified customer reviews
63% experienced reduced colic symptoms*
Parents report a noticeable reduction in colic symptoms within the first 30 days — fewer crying episodes, less gas, and a calmer, more settled baby. *Post-purchase customer survey.
What Pediatricians Are Saying
I recommend infant-specific probiotics like Persephone’s synbiotic, which is designed to restore what nature intended every baby to have in those critical first months of life. 
Dr. Tanya Altman, MD
The Research That Started It All
7 YEARS
Of infant microbiome research behind every formula decision
400+ Samples
Of infant stool analyzed from 48 states. The largest U.S. study of its kind
50+ YEARS
Since B. Infantis started disappearing from the infant gut biome
1,000 DAYS
The critical window to build lifelong gut health — starting at birth
Why Choose Our Synbiotic?
Most baby probiotics are generic — often pulled from decades-old strain banks and sold without the food they need to colonize in the gut. Ours is different.
Real people. Real science. Here for you.
If you're not satisfied within 90 days, we'll make it right. No complicated process. No runaround.
Every purchase is backed by our 90 day Peace of Mind Promise
This isn’t just my company, it’s my calling.
I'm Stephanie, a mom, scientist and founder. Have questions about our product or your babies microbiome? We've got you.
FAQs
Yes. Both Bloom and Thrive are designed specifically for infants and toddlers, third-party tested at Eurofins for heavy metals, allergens, and contaminants, and certified by the Clean Label Project's First 1,000 Days Promise.
Most probiotics use generic strains isolated decades ago that have no ability to consume breast milk sugars. Persephone uses four proprietary strains from today's healthiest babies, precision-paired with the HMOs they've evolved to eat. It's a different category of product — not a better version of the same thing.
Most likely, yes. B. infantis has been declining in the Western gut for over 50 years — a multigenerational shift that predates your own mother's birth. Even the most health-conscious pregnancy can't fully reverse a trend that has been building for generations. Our My Baby Biome study found 9 in 10 babies missing B. infantis regardless of feeding method or birth type.
Every baby is different. Some parents notice changes in digestion and comfort within the first few weeks. Immune and long-term benefits build over months of consistent use. That's why we offer a 90-day guarantee. Meaningful gut health takes time, and we want you to have the space to see it work.
Some babies do best starting slow. Half a packet for the first few days. Minor adjustments are normal as the gut adapts. Our Care Team (real scientists and doctors, not a call center) is available to support you through the process personally.