Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Hey Gillian 👋
The sleep routine isn't broken. Their gut may be missing something.
In a survey of parents using Persephone, nearly 1 in 2 reported improvements in their baby's sleep within the first month.‡
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You've tried the swaddle. The white noise. The schedule. You find something that works, and three nights later you're back to square one.
Here's what nobody tells you: it might not be about the routine at all... it could be what's happening inside your baby's gut.
We're not the only ones looking at this
In a study of 162 infants, enrichment in Bifidobacterium was associated with significantly better sleep outcomes. (3)
Persephone's synergistic synbiotic (pre + probiotic) delivers 4 Keystone strains of beneficial Bifidobacterium bacteria plus precision paired HMO prebiotics for optimal effects.
47% of parents surveyed reported improved sleep after using Persephone for one month.*
What researchers think might be going on
The gut and the brain are in constant communication.4 What happens in one affects the others and in babies, that conversation starts very early.
Bifidobacterium produce short-chain fatty acids that support gut health.
A calmer, more settled gut may translate to a calmer, more settled baby — and more restful sleep.
Gut bacteria also appear to influence the body's production of natural sleep regulators.2
Researchers are still working to understand exactly how this plays out in infants, but the signal is there.
This is an emerging area of science.
We won't tell you it's settled — but we think the research is pointing somewhere important. And so do a growing number of pediatric researchers.
Most modern babies are missing gut microbes they were built to have.
C-sections, early formula use, and antibiotics disrupt the early transfer of Bifidobacterium from mother to infant. (1)
Bifidobacterium colonization is critical in the first 1,000 days to help the immune system develop
Persephone's daily synbiotic carefully restores the keystone bacteria babies are meant to have. So they can thrive as nature intended.
Better Sleep
Fewer Colic Symptoms
Bifidobacterium deficiency is associated with infant colic. 5
Calmer Digestion
less constipation and more regular
Reduced Diaper Rash
Immune Development
The first 1,000 days are when the immune system is most shaped by gut health
What Pediatricians Are Saying
I recommend infant-specific probiotics like Persephone’s synbiotic, which is designed to restore what nature intended every baby to have in those critical first months of life. 
Dr. Tanya Altman, MD
4
Keystone Strains
proprietary infant specific probiotics
HMO
Prebiotic Blend
the exact fuel the probiotics need to do their job
90
Day Peace of Mind Promise
We stand behind our product If you’re not satisfied for any reason, just reach out and we’ll make it right.
This isn’t just my company, it’s my calling.
I'm Stephanie, a mom, scientist and founder. Have questions about our product or your babies microbiome? We've got you.
Precision science furthering nature’s brilliance
At Persephone, we’ve harnessed the power of nature and science to develop a first-of-its kind synbiotic – pairing keystone probiotics with prebiotics found in human breast milk to nurture a thriving gut ecosystem during the most critical years of development.
Real people. Real science. Here for you.
If you're not satisfied within 90 days, we'll make it right. No complicated process. No runaround.
FAQs
Every baby is different. Some parents notice changes in digestion and comfort within the first few weeks. Immune and long-term benefits build over months of consistent use. That's why we offer a 90-day guarantee. Meaningful gut health takes time, and we want you to have the space to see it work.
Yes. Both Bloom and Thrive are designed specifically for infants and toddlers, third-party tested at Eurofins for heavy metals, allergens, and contaminants, and certified by the Clean Label Project's First 1,000 Days Promise.
Yes. Mix one packet into a single daily bottle of formula.
Pro Tip: Mix it into a smaller bottle or portion so you know your baby finishes the full serving.
Most likely, yes. B. infantis has been declining in the Western gut for over 50 years — a multigenerational shift that predates your own mother's birth. Even the most health-conscious pregnancy can't fully reverse a trend that has been building for generations. Our My Baby Biome study found 9 in 10 babies missing B. infantis regardless of feeding method or birth type.
Absolutely. 7+ years of research on this specific product plus many additional years on the microbiome. We also test every batch with a 3rd party.
Citations
- Jarman, J.B. et al. Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis. Commun Biol 8, 867 (2025). https://doi.org/10.1038/s42003-025-08274-7
- Hossain, M.F. et al. The gut-sleep axis in adults and infants. Open Life Sci (2023). https://doi.org/10.1515/biol-2022-0910
- Lauritzen, L. et al. Bifidobacterium and sleep in infants: a study of 162 infants. Prog Neurobiol (2021). https://doi.org/10.1016/j.pneurobio.2021.102208
- Hepsomali, P. & Groeger, J.A. Diet, gut microbiota, and sleep. Sleep Med Rev (2021). https://doi.org/10.1016/j.smrv.2020.101340
- Mu, S., et al. (2023). Bifidobacterium and infantile colic. Scientific Reports. https://doi.org/10.1038/s41598-023-36641-z
‡Based on a survey of parents whose infants used Persephone for at least one month. Individual results may vary.