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Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Exclusive Offer: 30% Off 1st Order* with code SAVE30
Hey Gillian 👋
If your baby just finished antibiotics, the window to rebuild your baby's gut is already open
Antibiotics helped your baby, but a single course may have reduced the beneficial bacteria in their gut, the same bacteria that train their immune system and support digestion.
Persephone is an infant-specific synbiotic designed to help replenish key beneficial bacteria that may be reduced after antibiotic use.
What's actually happening
Antibiotics can't tell the good bacteria from the bad
The medicine goes to work. Antibiotics clear out the bacteria behind the infection. That's exactly what you want when your little one is sick.
Helpful bacteria take a hit too. Along the way, good bacteria like Bifidobacterium can drop. These are the microbes that help your baby's gut do its everyday work.
The change can linger. Research suggests the gut community can stay changed for a while after the last dose — which is why the days after matter.3
Why the timing matters for your baby
The early years are when the microbiome is being built
A course of antibiotics during these years isn't just a one-week event. It can nudge a system that's still finding its footing. The good news: this is also when a little support can go a long way.
2 out of 3
babies in the U.S. have had a course of antibiotics by around age two.1 You are far from alone.
9 out of 10
U.S. babies in our research were missing B. infantis, a key gut microbe — even before any antibiotics.2
After antibiotics, help beneficial bacteria settle back in and give them the right food so they can stay.
That’s where most baby probiotics fall short. They add beneficial bacteria, but they often leave out the nutrients those bacteria need to thrive. Without the right food, the bacteria may not stick around long enough to make a lasting difference.
Persephone is a synergistic synbiotic: the right bacteria, paired with the exact food they've evolved to live on. Together, they don't just arrive. They thrive.
Our pre and probiotics don't just work together, they evolved together.
Where Persephone Fits In
At Persephone, this is exactly what we’re built around. We focus on restoring what modern life has disrupted.
Pediatrician Recommended
I recommend infant-specific probiotics like Persephone’s synbiotic, which is designed to restore what nature intended every baby to have in those critical first months of life. 
Dr. Tanya Altman, MD
FAQs
Many parents start once the antibiotic course is finished — but your pediatrician knows your baby best, so it's always worth a quick chat. Persephone comes as one daily powder stick. Mix it into milk, formula, or a little soft food. One stick a day.
It's different for every baby. Research suggests the gut community can stay changed for a while after the last dose, which is why the days and weeks afterward are a helpful time to give the gut some support.
Yes. Both Bloom and Thrive are designed specifically for infants and toddlers, third-party tested at Eurofins for heavy metals, allergens, and contaminants, and certified by the Clean Label Project's First 1,000 Days Promise.
Yes. Antibiotics are made to clear out the bacteria making your baby sick — but they can't tell the good kind from the bad. So they also lower helpful bacteria like Bifidobacterium that your baby's gut is still building. This is normal and well understood, not a sign you did anything wrong.
Most probiotics use generic strains isolated decades ago that have no ability to consume breast milk sugars. Persephone uses four proprietary strains from today's healthiest babies, precision-paired with the HMOs they've evolved to eat. It's a different category of product — not a better version of the same thing.
Give their gut a little help bouncing back.
References
- https://www.mayoclinicproceedings.org/article/s0025-6196(20)30785-0/fulltext.
- Jarman, J.B., Torres, P.J., Stromberg, S. et al. Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis. Commun Biol 8, 867 (2025). https://doi.org/10.1038/s42003-025-08274-7.
- https://www.nature.com/articles/s41591-026-04284-y