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Frequently Asked Questions

What is Our Synbiotic?

Persephone’s Daily Synergistic Synbiotic is the first-of-its-kind pre + probiotic made just for modern babies and toddlers. It combines 4 keystone probiotic strains that naturally belong in a baby’s gut with special prebiotics from breast milk that help them grow and thrive.

Product / How to Use

Mix one packet into a single daily bottle of breastmilk or formula.

Pro Tip: Mix it into a smaller bottle or portion so you know your baby finishes the full serving.

One packet, every day. Consistency is what helps their gut bacteria thrive.

Pro Tip: Keep the box next to wherever your routine starts, bottles, snacks, or even the coffee pot, so it’s easy to remember every day.

Through the first three years of life — the critical window when the gut and immune system are being shaped. Daily use helps protect against modern disruptions that cause most babies to miss out on the good bacteria they need.

Try a “low and slow” approach: begin with half a packet for a few days, then increase to a full packet once their tummy adjusts.

No need to redose, just wait and give the next day’s serving as usual.

We get it, it’s hard to remember everything! If you miss a day, just pick back up with the next day’s packet. Missing a dose once in a while isn’t a problem. What matters most is keeping it part of your child’s regular routine over time so the good bacteria can do their job.

Pro Tip: Keep the box somewhere you already go every day, near bottles, snacks, or even your coffee pot, so it’s easier to remember.

Anytime works! What matters most is giving it consistently at the same time each day so it becomes part of your routine (and less likely to get forgotten).

Many parents like mornings — it’s easy to mix in with breakfast or the first feed, and you can keep an eye on how your little one responds during the day.

Mix into cold or room-temp foods (like yogurt, applesauce, or smoothies) or drinks (milk is better than water due to the HMOs). It dissolves completely and has no taste.

Pro Tip: Add to their favorite foods, or include your toddler in the process.

Mix the powder with a few drops of breastmilk to make a paste and apply to your nipple, finger, or pacifier. Or mix with a teaspoon of breastmilk and give with a small syringe.

Pro Tip: If you’re using the syringe method, slip it into the corner of your baby’s mouth while they’re calm for the easiest feed.

Ingredients & Allergies

Four carefully chosen Bifidobacterium strains (the good gut bacteria babies are often missing), a blend of Human Milk Oligosaccharides (nature-identical prebiotics), and Vitamin D.

It’s third-party tested and free from major allergens such as peanuts, soy, gluten, and shellfish. Because HMOs are derived from lactose, there may be trace amounts of dairy. It is safe for most babies but not recommended for those with a severe dairy allergy. The product is vegetarian and kosher, though not vegan.

Nothing! It’s completely flavorless and dissolves fully. Your child won’t even know it’s there.

Pro Tip: If you have a picky toddler, mix it into a food or drink they already love — it blends right in without changing taste or texture.

Nope!  it’s totally shelf-stable at room temperature. We always recommend to store it in a cool, dry place out of direct sunlight.

General Questions

Yes, it can actually help restore balance after antibiotics. If you can, give it a few hours away from the antibiotic dose. (It's always good to check with your pediatrician, too.)

Yes. Even in those situations, research shows 9 out of 10 babies in the U.S. are still missing key Bifidobacterium. Giving their gut what it needs early helps set up their immune system for the long run.

It's can be completely normal, it just means their gut is adjusting. Try starting “low and slow” with a pinch, then half a packet for a few days, then work up to a full packet. If discomfort continues for more than two weeks, pause and check in with your pediatrician.

No need to double up. Our synbiotic was designed to have all the probiotics and prebiotics your baby’s gut needs. Adding other probiotics can sometimes overwhelm a young gut, so we recommend sticking with just this one unless your pediatrician advises otherwise.

Our synbiotic isn’t a treatment or medicine, it can’t replace your doctor’s guidance. But sometimes symptoms like gassiness, eczema, or constipation are linked to gut imbalance. Supporting the microbiome can help ease those issues.

Yes! While our product was specifically studied in children under 3 (when the gut and immune system are developing the fastest), the ingredients are completely safe at any age and can still provide benefits.

In fact, many of our own team members, including the founders, give it to their older kids and even take it themselves. The probiotic strains, HMOs, and Vitamin D are all safe beyond age 3 and continue to support gut and immune health as children grow.

Think of it this way: the first three years are the most important window to establish a healthy gut foundation, but keeping those good bacteria supported is a positive step for everyone in the family.

Pro Tip: For older kids, you can easily mix it into smoothies, yogurt, or other favorite foods — it blends right in with no taste.

Safety & Quality

Yes. Probiotics have been studied in thousands of infants and are generally very well tolerated. We go above and beyond to make sure our product is safe for your little one:

  • Every batch is made in the U.S. with globally sourced ingredients
  • Manufactured under strict Good Manufacturing Practices (GMP)
  • Third-party tested for purity, allergens, and contaminants
  • Certified by the Clean Label Project’s First 1,000 Days Promise, which sets the toughest standards for products made for moms, infants, and toddlers
  • Clinically validated in Artemis, Persephone’s randomized, double-blind, placebo-controlled study, the largest infant/toddler microbiome trial of its kind in the U.S.

Dietary supplements aren’t regulated like medications, so they don’t go through FDA approval. However, all of our ingredients are classified as “Generally Recognized as Safe” (GRAS). On top of that, we voluntarily conduct third-party testing on every batch so you can feel confident about what you’re giving your child.

If your baby was born prematurely, has a weakened immune system, or a medical condition, it’s best to check with your pediatrician before starting any supplement. For healthy, full-term babies and toddlers, our synbiotic is safe and designed specifically for early life.

Ordering & Subscriptions

Your subscription comes with automatic deliveries, free shipping, monthly savings, access to our parent Facebook community, a special welcome package with extra goodies.

You can manage your subscription anytime — skip, change, or cancel — it’s quick and easy.

  1. Click here to log into your account.
  2. Enter the email address you used when purchasing.
  3. We’ll send you a secure one-time link to access your account (no password required!).
  4. From there, you can update, skip, or cancel your subscription, no hidden hoops.

Yes! Subscriptions always ship free. One-time purchases have a shipping and handling fee.

Orders ship within 1 business day and usually arrive in 3–5 days. You’ll get a tracking link as soon as it’s on the way.

Yes — we partner with Truemed so you can use your pre-tax HSA or FSA dollars. You can access your Truemed qualification link through your order confirmation email or through this link.

We stand behind our product with a 90-day Peace of Mind Promise. If you’re not satisfied for any reason, just reach out to our Care Team at care@persephone.com and we’ll make it right.