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1 in 3 babies arrives by C-section. Here's the gut science every one of their parents deserves to know.
The first 1,000 days of life are the most critical window for your baby's gut development.
That foundation is still forming. Persephone puts back what every baby was meant to have.
You can help rebuild what they missed, and Persephone was built to do exactly that.
Replenishes the bacteria C-section babies miss1
Supports immune system development.
Promotes healthy digestion
Designed for the critical first 1,000 days
"As a pediatrician, I regularly see babies born by C-section who struggle with gas, fussiness, or digestive discomfort and are often missing key Biffidobacteria in their gut microbiome...
While every baby is different, I have found that restoring these important infant-specific bacteria can be a valuable part of helping babies feel more comfortable and supporting healthy development from the start."
- Dr. Tanya Altman, MD, Pediatrician
Why a C-section Baby Needs Microbiome Support
Missing out on mom's protective microbes: during C-section babies miss the beneficial bacteria transfer from mom and can experience a significant delay in acquiring essential, healthy microbes like Bifidobacterium.3
Because C-section babies are not initially colonized by their mother's natural microbiome, their guts can become populated by opportunistic bacteria commonly found on the skin or in hospital environments.2
Crucial immune system training: The bacteria in a newborn's gut actively teach and train their immature immune system. The bacterial imbalance (dysbiosis) caused by a surgical birth and the accompanying antibiotics can delay or alter this critical immune development.3
Where Persephone Fits In
Persephone was built to replenish the microbes Mother Nature intended babies to have, natually.
In my practice, I have seen that supporting the microbiome with specific biffidobacteria strains along with HMOs, can help babies become more comfortable, feed better, and thrive during the first months of life. 
Dr. Tanya Altman, MD
Real people. Real science. Here for you.
If you're not satisfied within 90 days, we'll make it right. No complicated process. No runaround.
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This isn’t just my company, it’s my calling.
I'm Stephanie, a mom, scientist and founder. Have questions about our product or your babies microbiome? We've got you.
4
Keystone Strains
of infant/toddler specific probiotics
HMO
prebiotic blend
to promote bacterial longevity in the gut
100%
daily recommended value of Vitamin D for infants
FAQs
Yes. Both Bloom and Thrive are designed specifically for infants and toddlers, third-party tested at Eurofins for heavy metals, allergens, and contaminants, and certified by the Clean Label Project's First 1,000 Days Promise.
Babies born by cesarean section, or C-section, typically have a different early exposure. Instead of vaginal microbes, they are more likely to encounter bacteria from the skin, the hospital environment, and the operating room.
Most probiotics use generic strains isolated decades ago that have no ability to consume breast milk sugars. Persephone uses four proprietary strains from today's healthiest babies, precision-paired with the HMOs they've evolved to eat. It's a different category of product — not a better version of the same thing.
References
- My Baby Biome Study: Jarman, J.B., Torres, P.J., Stromberg, S. et al. Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis. Commun Biol 8, 867 (2025).
- Shao, Y., Forster, S.C., Tsaliki, E. et al. Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth. Nature 574, 117–121 (2019).
- Hoang DM, Levy EI, Vandenplas Y. The impact of Caesarean section on the infant gut microbiome. Acta Paediatr. 2021;110:60–67.